{
 "schema_version": 1,
 "generated": "2026-10-31",
 "repo": "RosettaCommons/RFdiffusion",
 "name": "RFdiffusion",
 "owner": "RosettaCommons",
 "slug": "rosettacommons-rfdiffusion",
 "github": "https://github.com/RosettaCommons/RFdiffusion",
 "what": "RFdiffusion is an open source diffusion model for protein structure generation. It does unconditional monomer generation, motif scaffolding, binder design against a target chain with hotspot residues, partial diffusion around an existing design, fold conditioning, and symmetric oligomer generation. Everything runs through scripts/run_inference.py with hydra config overrides.",
 "why": "3.1k stars, picked up by one AI source we track",
 "language": "",
 "requirements": [
  "A clone of the repo plus the model weights downloaded into its models folder",
  "Anaconda or Miniconda, and NVIDIA's SE(3)-Transformer installed from the env folder",
  "An NVIDIA GPU; the provided environment file targets CUDA 11.1 and may need adapting",
  "Docker as an alternative to the conda setup, using the provided docker/Dockerfile"
 ],
 "audience_note": "Protein designers and computational biology teams exploring de novo backbones and binders.",
 "risk": "none",
 "section": "earlier",
 "weekly_rank": null,
 "category": "Security and science",
 "url": "https://dedupedai.com/use-cases/rosettacommons-rfdiffusion/",
 "use_case_count": 3,
 "use_cases": [
  {
   "id": "rosettacommons-rfdiffusion--generate-de-novo-protein-backbones-with-rfdiffusion",
   "title": "Generate new protein backbones from scratch",
   "best": true,
   "url": "https://dedupedai.com/use-cases/rosettacommons-rfdiffusion/generate-de-novo-protein-backbones-with-rfdiffusion/",
   "json": "https://dedupedai.com/use-cases/u/rosettacommons-rfdiffusion/generate-de-novo-protein-backbones-with-rfdiffusion.json"
  },
  {
   "id": "rosettacommons-rfdiffusion--design-a-binder-to-a-target-with-rfdiffusion",
   "title": "Design a binder against a target protein",
   "best": false,
   "url": "https://dedupedai.com/use-cases/rosettacommons-rfdiffusion/design-a-binder-to-a-target-with-rfdiffusion/",
   "json": "https://dedupedai.com/use-cases/u/rosettacommons-rfdiffusion/design-a-binder-to-a-target-with-rfdiffusion.json"
  },
  {
   "id": "rosettacommons-rfdiffusion--scaffold-a-functional-motif-with-rfdiffusion",
   "title": "Scaffold a functional motif into a new protein",
   "best": false,
   "url": "https://dedupedai.com/use-cases/rosettacommons-rfdiffusion/scaffold-a-functional-motif-with-rfdiffusion/",
   "json": "https://dedupedai.com/use-cases/u/rosettacommons-rfdiffusion/scaffold-a-functional-motif-with-rfdiffusion.json"
  }
 ],
 "disclaimer": "Third-party repos we don't own or vouch for. AI-generated use cases can be wrong: review everything and run at your own risk."
}