{
 "schema_version": 1,
 "generated": "2026-10-31",
 "repo": "sokrypton/ColabFold",
 "name": "ColabFold",
 "owner": "sokrypton",
 "slug": "sokrypton-colabfold",
 "github": "https://github.com/sokrypton/ColabFold",
 "what": "ColabFold makes protein structure prediction accessible through Google Colab notebooks for AlphaFold2 with MMseqs2, AlphaFold3 (OpenFold3), ESMFold, batch runs and beta models such as RoseTTAFold2, Boltz and BioEmu. It also runs locally: colabfold_search builds multiple sequence alignments against the ColabFold databases (with optional GPU-accelerated MMseqs2-GPU search) and colabfold_batch predicts structures, and both can export MSAs as AlphaFold3-compatible JSON.",
 "why": "3k stars, talked about in 2 AI sources we track",
 "language": "Jupyter Notebook",
 "requirements": [
  "A Google account for the Colab notebooks, or a local ColabFold install for colabfold_search and colabfold_batch",
  "For local searches: MMseqs2 and the ColabFold databases (large downloads, a lot of CPU)",
  "A GPU for structure prediction; about 16 GB of GPU memory handles sequences up to roughly 2000 residues",
  "For GPU search: GPU databases set up with GPU=1"
 ],
 "audience_note": "Researchers and students who want protein folding without their own cluster, and labs that run many predictions locally.",
 "risk": "none",
 "section": "earlier",
 "weekly_rank": null,
 "category": "Security and science",
 "url": "https://dedupedai.com/use-cases/sokrypton-colabfold/",
 "use_case_count": 3,
 "use_cases": [
  {
   "id": "sokrypton-colabfold--fold-a-protein-in-a-colab-notebook",
   "title": "Fold a protein in a free Colab notebook",
   "best": true,
   "url": "https://dedupedai.com/use-cases/sokrypton-colabfold/fold-a-protein-in-a-colab-notebook/",
   "json": "https://dedupedai.com/use-cases/u/sokrypton-colabfold/fold-a-protein-in-a-colab-notebook.json"
  },
  {
   "id": "sokrypton-colabfold--batch-fold-many-proteins-locally-with-colabfold",
   "title": "Batch-fold many proteins on your own machines",
   "best": false,
   "url": "https://dedupedai.com/use-cases/sokrypton-colabfold/batch-fold-many-proteins-locally-with-colabfold/",
   "json": "https://dedupedai.com/use-cases/u/sokrypton-colabfold/batch-fold-many-proteins-locally-with-colabfold.json"
  },
  {
   "id": "sokrypton-colabfold--prepare-alphafold3-inputs-with-colabfold-msas",
   "title": "Prepare AlphaFold3 inputs with Colab Fold alignments",
   "best": false,
   "url": "https://dedupedai.com/use-cases/sokrypton-colabfold/prepare-alphafold3-inputs-with-colabfold-msas/",
   "json": "https://dedupedai.com/use-cases/u/sokrypton-colabfold/prepare-alphafold3-inputs-with-colabfold-msas.json"
  }
 ],
 "disclaimer": "Third-party repos we don't own or vouch for. AI-generated use cases can be wrong: review everything and run at your own risk."
}